The Science

Rooted in research

The science behind
functional mushrooms

We believe in transparency. Every mushroom in our formulas is backed by peer-reviewed research. Below you'll find the studies that inform our ingredients.

Research context: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Studies linked below are provided for informational purposes and represent ongoing research.
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Lion's Mane Hericium erinaceus

Found in Aypha Complete

Cognitive supportFocusMoodNerve health
Phytotherapy Research · 2009 RCT
Improving effects of Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
30 subjects aged 50–80 with mild cognitive impairment showed significant improvements in cognitive test scores after 16 weeks of Lion’s Mane supplementation versus placebo.
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Nutrients · 2023 RCT
Acute and chronic effects of Lion's Mane supplementation on cognitive function, stress, and mood in young adults: a double-blind, parallel-groups pilot study
41 healthy adults taking 1.8g Hericium erinaceus performed faster on cognitive tasks after a single dose, with a trend toward reduced subjective stress after 28 days. PMC10675414
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Frontiers in Nutrition · 2025 RCT
Acute effects of a standardised extract of Hericium erinaceus on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
Fruiting-body extract investigated for acute effects on executive function and working memory in adults aged 18–35. PMC12018234
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Reishi Ganoderma lucidum

Found in Aypha Calm

Stress supportMoodSleep qualityImmune balance
Journal of Medicinal Food · 2005 RCT
A randomized, double-blind, placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia
Participants taking Reishi polysaccharide extract for 8 weeks showed statistically significant improvements in fatigue and general well-being compared to placebo. PMID: 15857210
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Nutrients · 2022 Preclinical
Ganoderma lucidum triterpenoids improve maternal separation-induced anxiety- and depression-like behaviors in mice by mitigating inflammation
Reishi triterpenoids reduced anxiety- and depression-like behaviors through an anti-inflammatory mechanism. PMC9182879
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Phytotherapy Research · 2021 Review
Ganoderma lucidum: a comprehensive and critical review of its nutritional, pharmacological, clinical, and toxicological properties (2015–2020)
Comprehensive review documenting immunomodulatory, anti-fatigue, and stress-related bioactivities. PMID: 34411377
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Cordyceps Cordyceps militaris

Found in Aypha Complete

EnergyEnduranceOxygen utilizationVitality
Journal of Dietary Supplements · 2016 RCT
Cordyceps militaris improves tolerance to high-intensity exercise after acute and chronic supplementation
28 participants showed improved VO₂max and time-to-exhaustion after supplementation with a Cordyceps militaris blend. Greater benefits observed with consistent use. PMID: 27408987
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PMC · 2015 RCT
Chronic supplementation of a mushroom blend on oxygen kinetics, peak power, and time to exhaustion
3 weeks of Cordyceps militaris-containing blend (4g/day) may improve VO₂max, increase time-to-exhaustion, and augment peak power during high-intensity exercise. PMC4594151
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Systematic review & meta-analysis · 2025 Meta-analysis
Fungal supplementation on endurance, immune function, and hematological profiles in adult athletes
14 RCTs (n=528 athletes). Meta-analysis found Cordyceps sinensis supplementation significantly improved endurance performance, ventilatory threshold, and VO₂peak. PMC12631420
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Turkey Tail Trametes versicolor

Found in Aypha Complete

Immune supportGut healthAntioxidant
BMC Complementary Medicine · 2019 In vitro
The mycelium of Trametes versicolor (Turkey Tail) and its fermented substrate each show potent and complementary immune activating properties in vitro
Turkey Tail mycelium triggered robust activation of CD69 on human lymphocytes and monocytes, suggesting meaningful immune-modulating activity. PMC6889544
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Integrative Cancer Therapies · 2026 Review
The medicinal mushroom Trametes versicolor: reviewing preclinical and clinical evidence
Comprehensive clinical review documenting immunomodulatory, prebiotic, and antioxidative properties of Turkey Tail across preclinical and human trial data.
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PubMed · 2023 In vitro
Medicinal mushroom extracts from Trametes versicolor exert differential immunomodulatory effects on immune cells from older adults
Turkey Tail extracts modulated cytokine signaling (IL-1β, IL-6, IL-8) in peripheral blood cells from older adults in the presence of viral and bacterial stimuli. PMID: 37432355
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Chaga Inonotus obliquus

Found in Aypha Complete

AntioxidantAnti-inflammatoryDNA protection
Bioscience Biotechnology Biochemistry · 2005 In vitro
Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay
Aqueous Chaga extract protected human lymphocytes against hydrogen peroxide-induced oxidative DNA damage at multiple concentrations. PMID: 15630179
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International Journal of Molecular Sciences · 2023 In vitro
Protective effects of lanostane triterpenoids from Chaga mushroom in human keratinocytes against inflammatory and oxidative stresses
Inotodiol from Chaga significantly reduced IL-1β, IL-6, and IL-8 gene expression in human cells under TNF-α and UVB stimulation. PMC10454022
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Frontiers in Pharmacology · 2023 Review
Chaga mushroom: a super-fungus with countless facets and untapped potential
Comprehensive review of Chaga’s anti-inflammatory, immunomodulatory, hepatoprotective, and antioxidant properties. PMID: 38116085
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Maitake Grifola frondosa

Found in Aypha Complete

Immune supportBlood sugar balanceNK cell activity
Cancer Immunology Immunotherapy · 2009 Phase I/II Trial
A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake) in breast cancer patients: immunological effects
Oral Maitake extract in 34 patients produced statistically significant measurable effects on immune function (p<0.0005). PMID: 19253021
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PubMed · 2014 Animal
Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts
Short-term oral application of Maitake glucans strongly stimulated both cellular and humoral immune responses, significantly outperforming AHCC in direct comparison. PMID: 25332990
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PMC · 2025 Animal
Grifola frondosa polysaccharide F2 ameliorates disordered glucose and lipid metabolism in prediabetic mice
Maitake polysaccharide reduced fasting blood glucose, lipid profile, and insulin resistance in prediabetic mice via gut microbiota and bile acid modulation. PMC11941230
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All studies are indexed on PubMed or published in peer-reviewed journals. Study types are labeled above each citation. Results may vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.